Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rescue of the acetylcholinesterase knockout mouse by feeding a liquid diet; phenotype of the adult acetylcholinesterase deficient mouse.

Brain research. Developmental brain research - 30 Jul 2002

Duysen Ellen G, Stribley Judith A, Fry Debra L, Hinrichs Steven H, Lockridge Oksana

Abstract excerpt

Acetylcholinesterase (AChE, EC3.1.1.7) functions in nerve impulse transmission, and possibly as a cell adhesion factor during neurite outgrowth. These functions predicted that a mouse with zero AChE activity would be unable to live. It was a surprise to find that AChE -/- mice were born alive and survived an average of 14 days. The emaciated appearance of AChE -/- mice suggested an inability to obtain sufficient...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylcholinesterase
Share to Animals, Suckling

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Body Temperature

Share to Dietary Sucrose

Share to Vocalization, Animal

Share to Weaning

Source

Identifiers

PMID: 12128253
DOI: 10.1016/s0165-3806(02)00367-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rescue of the acetylcholinesterase knockout mouse by feeding a liquid diet; phenotype of the adult acetylcholinesterase deficient mouse.PMID 12128253Read ↗

Are there non-catalytic functions of acetylcholinesterases? Lessons from mutant animal models.Semantic proximity Read ↗

Acetylcholinesterase plays a non-neuronal, non-esterase role in organogenesisSemantic proximity Read ↗

Knockout of one acetylcholinesterase allele in the mouse.Semantic proximity Read ↗

Behavioral phenotyping of heterozygous acetylcholinesterase knockout (AChE+/-) mice showed no memory enhancement but hyposensitivity to amnesic drugs.Semantic proximity Read ↗

Acetylcholinesterase (AChE) gene modification in transgenic animals: functional consequences of selected exon and regulatory region deletion.Semantic proximity Read ↗

Phenotype comparison of three acetylcholinesterase knockout strains.Semantic proximity Read ↗

Acetylcholinesterase is required for neuronal and muscular development in the zebrafish embryo.Semantic proximity Read ↗

Early weaning and culling eradicated Helicobacter hepaticus from an acetylcholinesterase knockout 129S6/SvEvTac mouse colony.Semantic proximity Read ↗

Respiratory survival mechanisms in acetylcholinesterase knockout mouse.Semantic proximity Read ↗

Delivery of human acetylcholinesterase by adeno-associated virus to the acetylcholinesterase knockout mouse.Semantic proximity Read ↗

A mouse model of AChR deficiency syndrome with a phenotype reflecting the human condition.Semantic proximity Read ↗

Lethal impairment of cholinergic neurotransmission in hemicholinium-3-sensitive choline transporter knockout mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.