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Article

Dysautonomia due to reduced cholinergic neurotransmission causes cardiac remodeling and heart failure.

Molecular and cellular biology - 1 Apr 2010

Lara Aline, Damasceno Denis D, Pires Rita, Gros Robert, Gomes Enéas R, Gavioli Mariana, Lima Ricardo F, Guimarães Diogo, Lima Patricia, Bueno Carlos Roberto, Vasconcelos Anilton, Roman-Campos Danilo, Menezes Cristiane A S, Sirvente Raquel A, Salemi Vera M, Mady Charles, Caron Marc G, Ferreira Anderson J, Brum Patricia C, Resende Rodrigo R, Cruz Jader S, Gomez Marcus Vinicius, Prado Vania F, de Almeida Alvair P, Prado Marco A M, Guatimosim Silvia

Abstract excerpt

Overwhelming evidence supports the importance of the sympathetic nervous system in heart failure. In contrast, much less is known about the role of failing cholinergic neurotransmission in cardiac disease. By using a unique genetically modified mouse line with reduced expression of the vesicular acetylcholine transporter (VAChT) and consequently decreased release of acetylcholine, we investigated the consequences...

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Echocardiography
Heart Failure
Heart Rate
Hemodynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sarcoplasmic Reticulum Calcium-Transporting ATPases

Sympathetic Nervous System

Synaptic Transmission

Ventricular Remodeling

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Identifiers

PMID: 20123977
DOI: 10.1128/MCB.00996-09
PMCID: PMC2838086

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