Article
Association between ABCB1-T1236C polymorphism and drug-resistant epilepsy in Iranian female patients.
Iranian biomedical journal - 1 Jul 2010
Maleki Mehri, Sayyah Mohammad, Kamgarpour Fatemeh, Karimipoor Morteza, Arab Aida, Rajabi Anahita, Gharagozli Kourosh, Shamshiri Ahmad Reza, Shahsavand Ananloo Esmaeil
Abstract excerpt
BACKGROUND: One third of epileptic patients are resistant to several anti-epileptic drugs (AED). P-glycoprotein (P-gp) is an efflux transporter encoded by ATP-binding cassette subfamily B member 1 (ABCB1) gene that excludes drugs from the cells and plays a significant role in AEDs resistance. Ove...
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