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Article

ABCB1 polymorphisms influence the response to antiepileptic drugs in Japanese epilepsy patients.

Pharmacogenomics - 1 Jun 2006

Seo Takayuki, Ishitsu Takateru, Ueda Nao, Nakada Naoyuki, Yurube Keigo, Ueda Kentaro, Nakagawa Kazuko

Abstract excerpt

OBJECTIVES: The efflux transporter P-glycoprotein encoded by the ATP-binding cassette (ABC)B1 gene may play a role in drug-resistant epilepsy by limiting gastrointestinal absorption and brain access of antiepileptic drugs (AEDs). Our objective was to investigate the effect of ABCB1 polymorphisms on AED responsiveness and on the pharmacokinetics of carbamazepine (CBZ) in epileptic patients with the indication for...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16753003
DOI: 10.2217/14622416.7.4.551

Genes

ABCB1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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