Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deciphering the signature of selective constraints on cancerous mitochondrial genome.

Molecular biology and evolution - 1 Apr 2012

Liu Jia, Wang Li-Dong, Sun Yan-Bo, Li En-Min, Xu Li-Yan, Zhang Ya-Ping, Yao Yong-Gang, Kong Qing-Peng

Abstract excerpt

In accordance with the hypothesis that cancer formation is a process of somatic evolution driven by natural selection, signature of positive selection has been detected on a number of cancer-related nuclear genes. It remains, however, controversial whether a similar selective pressure has also acted on mitochondrial DNA (mtDNA), a small molecule in mitochondrion that may play an important role in tumorigenesis by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Databases, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Mitochondrial

Share to Esophageal Neoplasms

Share to Genome, Mitochondrial

Share to Molecular Sequence Data

Share to Phylogeny

Share to Selection, Genetic

Source

Identifiers

PMID: 22130971
DOI: 10.1093/molbev/msr290

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deciphering the signature of selective constraints on cancerous mitochondrial genome.PMID 22130971Read ↗

Heteroplasmic shifts in tumor mitochondrial genomes reveal tissue-specific signals of relaxed and positive selection.Semantic proximity Read ↗

MtDNA mutation pattern in tumors and human evolution are shaped by similar selective constraints.Semantic proximity Read ↗

Mutational profiling of mtDNA control region reveals tumor-specific evolutionary selection involved in mitochondrial dysfunction.Semantic proximity Read ↗

Mutational signature of mtDNA confers mechanistic insight into oxidative metabolism remodeling in colorectal cancer.Semantic proximity Read ↗

Functional Role of Mitochondrial DNA in Cancer Progression.Semantic proximity Read ↗

Mutational profiling of mitochondrial DNA reveals an epithelial ovarian cancer-specific evolutionary pattern contributing to high oxidative metabolism.Semantic proximity Read ↗

Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer.Semantic proximity Read ↗

Uncovering the profile of somatic mtDNA mutations in Chinese colorectal cancer patients.Semantic proximity Read ↗

Generation, function, and prognostic utility of somatic mitochondrial DNA mutations in cancer.Semantic proximity Read ↗

The landscape of mitochondrial DNA variation in human colorectal cancer on the background of phylogenetic knowledge.Semantic proximity Read ↗

Mitochondrial DNA mutations in cancer: a review.Semantic proximity Read ↗

Role of Mitochondrial DNA (mtDNA) Variations in Cancer Development: A Systematic Review.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.