Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The search for longevity and healthy aging genes: insights from epidemiological studies and samples of long-lived individuals.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 May 2012

Murabito Joanne M, Yuan Rong, Lunetta Kathryn L

Abstract excerpt

Genetic factors clearly contribute to exceptional longevity and healthy aging in humans, yet the identification of the underlying genes remains a challenge. Longevity is a complex phenotype with modest heritability. Age-related phenotypes with higher heritability may have greater success in gene discovery. Candidate gene and genome-wide association studies (GWAS) for longevity have had only limited success to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Aging

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease

Share to Genetic Association Studies

Share to Genome, Human

Share to Genome-Wide Association Study

Share to Longevity

Share to Risk Assessment

Source

Open in PubMed Open full text

Identifiers

PMID: 22499766
DOI: 10.1093/gerona/gls089
PMCID: PMC3326242

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The search for longevity and healthy aging genes: insights from epidemiological studies and samples of long-lived individuals.PMID 22499766Read ↗

Mice as a Mammalian Model for Research on the Genetics of AgingSemantic proximity Read ↗

Genome-wide approaches to understanding human ageing.Semantic proximity Read ↗

A genetic and genomic approach to identify longevity genes in mice.Semantic proximity Read ↗

Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study.Semantic proximity Read ↗

The quest for genetic determinants of human longevity: challenges and insights.Semantic proximity Read ↗

Genetics of healthy aging and longevity.Semantic proximity Read ↗

Genomics of human longevitySemantic proximity Read ↗

Genetic factors and epigenetic mechanisms of longevity: current perspectives.Semantic proximity Read ↗

Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.Semantic proximity Read ↗

LongevityMap: a database of human genetic variants associated with longevity.Semantic proximity Read ↗

Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity.Semantic proximity Read ↗

Identifying the genomic determinants of aging and longevity in human population studies: progress and challenges.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.