Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The quest for genetic determinants of human longevity: challenges and insights.

Nature reviews. Genetics - 1 Jun 2006

Christensen Kaare, Johnson Thomas E, Vaupel James W

Abstract excerpt

Twin studies show that genetic differences account for about a quarter of the variance in adult human lifespan. Common polymorphisms that have a modest effect on lifespan have been identified in one gene, APOE, providing hope that other genetic determinants can be uncovered. However, although variants with substantial beneficial effects have been proposed to exist and several candidates have been put forward,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Birth, Development, and Health
Share to APOE gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Associations and Epidemiology

Share to Genetic Linkage

Share to Genetics, Aging, and Longevity in Model Organisms

Share to Longevity

Source

Open in PubMed Open full text

Identifiers

PMID: 16708071
DOI: 10.1038/nrg1871
PMCID: PMC2726954

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The quest for genetic determinants of human longevity: challenges and insights.PMID 16708071Read ↗

A Prospective Analysis of Genetic Variants Associated with Human LifespanSemantic proximity Read ↗

The role of genetic variants in human longevity.Semantic proximity Read ↗

Identifying the genomic determinants of aging and longevity in human population studies: progress and challenges.Semantic proximity Read ↗

LongevityMap: a database of human genetic variants associated with longevity.Semantic proximity Read ↗

Genomics of human longevitySemantic proximity Read ↗

Genetics of Human Longevity Within an Eco-Evolutionary Nature-Nurture FrameworkSemantic proximity Read ↗

Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participantsSemantic proximity Read ↗

The genetics of human longevitySemantic proximity Read ↗

Genetics of human longevity: From variants to genes to pathwaysSemantic proximity Read ↗

Causes, effects, and constraints in the genetics of human longevity.Semantic proximity Read ↗

Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study.Semantic proximity Read ↗

Untangling the Genetics of Human Longevity—A Challenging QuestSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.