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Article

Mutation-selection-drift balance models of complex diseases.

Genetics - 10 Dec 2025

Berg Jeremy J, Li Xinyi, Riall Kellen, Hayward Laura K, Sella Guy

Abstract excerpt

Genetic variation that influences complex disease susceptibility is introduced into the population by mutation and removed by natural selection and genetic drift. This mutation-selection-drift balance (MSDB) shapes the prevalence of a disease and its genetic architecture. To date, however, MSDB has been modeled only for monogenic (Mendelian) diseases. Here, we develop an MSDB model for complex disease...

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Identifiers

PMID: 41073879
DOI: 10.1093/genetics/iyaf220
PMCID: PMC12693578

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