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Article

How Can We Explain Very Low Odds Ratios in GWAS? I. Polygenic Models.

Human heredity - 1 Jan 2016

Hodge Susan E, Greenberg David A

Abstract excerpt

Genome-wide association studies of common diseases often identify a number of disease-related SNPs that reach highly significant p values but at the same time show very low disease odds ratios (ORs), most <1.5 and many <1.2. Despite their statistical significance, associations involving very low ORs explain little about the genetic contribution to the disease and nothing about disease inheritance. A commonly...

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PMID: 28171865
DOI: 10.1159/000454804

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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