A new HLA map of Europe: Regional genetic variation and its implication for peopling history, disease-association studies and tissue transplantation.

doi:10.1159/000360855

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Article

A new HLA map of Europe: Regional genetic variation and its implication for peopling history, disease-association studies and tissue transplantation.

Human heredity - 1 Jan 2013

Sanchez-Mazas Alicia, Buhler Stéphane, Nunes José Manuel

Abstract excerpt

OBJECTIVES: HLA genes are highly polymorphic in human populations as a result of diversifying selection related to their immune function. However, HLA geographic variation worldwide suggests that demographic factors also shaped their evolution. We here analyzed in detail HLA genetic variation in Europe in order to identify signatures of migration history and/or natural selection. METHODS: Relationships between...

Topics

Disease
Europe
Genetic Association Studies
Genetic Loci
Genetic Variation
Genetics, Population
Geography
HLA Antigens
Haplotypes
Humans
Linear Models
Phenotype
Transplantation

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Open in PubMed

Identifiers

PMID: 24861861
DOI: 10.1159/000360855

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