Article
Locus and population specific evolution in HLA class II genes.
Annals of human genetics - 1 Jan 1999
Valdes A M, McWeeney S K, Meyer D, Nelson M P, Thomson G
Abstract excerpt
The population genetics of the HLA class II loci was studied with reference to variation in the frequency of (a) alleles at a locus and (b) amino acids at specific sites. Variation was surveyed at 4 loci (DRB1, DQA1, DQB1, and DPB1) in 22 populations from the Twelfth International Histocompatibility Workshop (Saint-Malo, 1996). Allele and amino acid variation was measured by computing heterozygosity and the...
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