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Article

Sae2 and Rif2 regulate MRX endonuclease activity at DNA double-strand breaks in opposite manners.

Cell reports - 30 Mar 2021

Marsella Antonio, Gobbini Elisa, Cassani Corinne, Tisi Renata, Cannavo Elda, Reginato Giordano, Cejka Petr, Longhese Maria Pia

Abstract excerpt

The Mre11-Rad50-Xrs2 (MRX) complex detects and processes DNA double-strand breaks (DSBs). Its DNA binding and processing activities are regulated by transitions between an ATP-bound state and a post-hydrolysis cutting state that is nucleolytically active. Mre11 endonuclease activity is stimulated by Sae2, whose lack increases MRX persistence at DSBs and checkpoint activation. Here we show that the Rif2 protein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33789097
DOI: 10.1016/j.celrep.2021.108906
PMCID: PMC8028314

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Sae2 and Rif2 regulate MRX endonuclease activity at DNA double-strand breaks in opposite manners.PMID 33789097Read ↗

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