Article
Mechanism of MRX inhibition by Rif2 at telomeres.
Nature communications - 12 May 2021
Roisné-Hamelin Florian, Pobiega Sabrina, Jézéquel Kévin, Miron Simona, Dépagne Jordane, Veaute Xavier, Busso Didier, Du Marie-Hélène Le, Callebaut Isabelle, Charbonnier Jean-Baptiste, Cuniasse Philippe, Zinn-Justin Sophie, Marcand Stéphane
Abstract excerpt
Specific proteins present at telomeres ensure chromosome end stability, in large part through unknown mechanisms. In this work, we address how the Saccharomyces cerevisiae ORC-related Rif2 protein protects telomere. We show that the small N-terminal Rif2 BAT motif (Blocks Addition of Telomeres) previously known to limit telomere elongation and Tel1 activity is also sufficient to block NHEJ and 5' end resection....
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