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Article

Structurally distinct Mre11 domains mediate MRX functions in resection, end-tethering and DNA damage resistance.

Nucleic acids research - 6 Apr 2018

Cassani Corinne, Gobbini Elisa, Vertemara Jacopo, Wang Weibin, Marsella Antonio, Sung Patrick, Tisi Renata, Zampella Giuseppe, Longhese Maria Pia

Abstract excerpt

Sae2 cooperates with the Mre11-Rad50-Xrs2 (MRX) complex to initiate resection of DNA double-strand breaks (DSBs) and to maintain the DSB ends in close proximity to allow their repair. How these diverse MRX-Sae2 functions contribute to DNA damage resistance is not known. Here, we describe mre11 alleles that suppress the hypersensitivity of sae2Δ cells to genotoxic agents. By assessing the impact of these mutations...

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Identifiers

PMID: 29420790
DOI: 10.1093/nar/gky086
PMCID: PMC5888019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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