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ATM priming and end resection–coupled phosphorylation of MRE11 is important for fork protection and replication restart

18 Apr 2025

Abstract excerpt

The MRE11/RAD50/NBS1 (MRN) complex plays multiple roles in the maintenance of genome stability. MRN is associated with replication forks to preserve fork integrity and is also required for end resection at double-strand breaks (DSBs) to facilitate homologous recombination (HR). The critical need for proper control of the MRE11 nuclease activity is highlighted by the extensive nascent strand DNA degradation driven...

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PMID: 40249789
DOI: 10.1073/pnas.2422720122

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