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Article

Resequencing, haplotype construction and identification of novel variants of CYP2D6 in Mexican Mestizos.

Pharmacogenomics - 1 May 2011

Contreras Alejandra V, Monge-Cazares Tulia, Alfaro-Ruiz Luis, Hernandez-Morales Salvador, Miranda-Ortiz Haydee, Carrillo-Sanchez Karol, Jimenez-Sanchez Gerardo, Silva-Zolezzi Irma

Abstract excerpt

AIM: The CYP2D6 enzyme participates in the metabolism of commonly prescribed drugs: antidepressants, antipsychotics and antihypertensives. The CYP2D6 gene shows a high degree of interindividual and interethnic variability that influences its expression and function. Mexican Mestizos are a recently admixed population resulting from the combination of Amerindian, European and, to a lesser extent, African...

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Share to Cytochrome P-450 CYP2D6
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PMID: 21391885
DOI: 10.2217/pgs.11.8

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