Article
Distribution of CYP2D6 and CYP2C19 polymorphisms associated with poor metabolizer phenotype in five Amerindian groups and western Mestizos from Mexico.
Genetic testing and molecular biomarkers - 1 Sept 2012
Salazar-Flores Joel, Torres-Reyes Luis A, Martínez-Cortés Gabriela, Rubi-Castellanos Rodrigo, Sosa-Macías Martha, Muñoz-Valle José F, González-González César, Ramírez Angélica, Román Raquel, Méndez José L, Barrera Andrés, Torres Alfredo, Medina Rafael, Rangel-Villalobos Héctor
Abstract excerpt
BACKGROUND: The distribution of polymorphisms in the CYP2D6 and CYP2C19 genes allows inferring the potential risk for specific adverse drug reactions and lack of therapeutic effects in humans. This variability shows differences among human populations. The aim of this study was to analyze single-nucleotide polymorphisms related to a poor metabolizer (PM) phenotype in nonpreviously studied Amerindian groups and...
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