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Article

SNCA, MAPT, and GSK3B in Parkinson disease: a gene-gene interaction study.

European journal of neurology - 1 Jun 2011

Wider C, Vilariño-Güell C, Heckman M G, Jasinska-Myga B, Ortolaza-Soto A I, Diehl N N, Crook J E, Cobb S A, Bacon J A, Aasly J O, Gibson J M, Lynch T, Uitti R J, Wszolek Z K, Farrer M J, Ross O A

Abstract excerpt

BACKGROUND AND PURPOSE: Recent evidence suggests that variation in the SNCA, MAPT, and GSK3B genes interacts in affecting risk for Parkinson disease (PD). In the current study, we attempt to validate previously published findings, evaluating gene-gene interactions between SNCA, MAPT, and GSK3B in...

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Source

Identifiers

PMID: 21159074
DOI: 10.1111/j.1468-1331.2010.03297.x

Genes

MAPT
SNCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21159074-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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SNCA, MAPT, and GSK3B in Parkinson disease: a gene-gene interaction study.PMID 21159074Read ↗

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Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.Semantic proximity Read ↗

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SNCA and MAPT genes: Independent and joint effects in Parkinson disease in the Italian population.Semantic proximity Read ↗

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Variants in the SNCA gene associate with motor progression while variants in the MAPT gene associate with the severity of Parkinson's disease.Semantic proximity Read ↗

Association of the MAPT locus with Parkinson's disease.Semantic proximity Read ↗

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