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Article

Interaction of alpha-synuclein and tau genotypes in Parkinson's disease.

Annals of neurology - 1 Mar 2005

Mamah Catherine E, Lesnick Timothy G, Lincoln Sarah J, Strain Kari J, de Andrade Mariza, Bower James H, Ahlskog J Eric, Rocca Walter A, Farrer Matthew J, Maraganore Demetrius M

Abstract excerpt

To determine whether the microtubule-associated protein tau (MAPT) and alpha-synuclein (SNCA) genes interact to confer Parkinson's disease (PD) susceptibility, we conducted a study of 557 case-control pairs. There was an increased risk of PD for persons with either SNCA 261/261 or MAPT H1/H1 genotypes as compared with persons with neither (odds ratio, 1.96; 95% confidence interval, 1.34-2.86; p = 0.0003)....

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Source

Identifiers

PMID: 15732111
DOI: 10.1002/ana.20387

Genes

MAPT
SNCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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