Article
Haplotypes and gene expression implicate the MAPT region for Parkinson disease: the GenePD Study.
Neurology - 1 Jul 2008
Tobin J E, Latourelle J C, Lew M F, Klein C, Suchowersky O, Shill H A, Golbe L I, Mark M H, Growdon J H, Wooten G F, Racette B A, Perlmutter J S, Watts R, Guttman M, Baker K B, Goldwurm S, Pezzoli G, Singer C, Saint-Hilaire M H, Hendricks A E, Williamson S, Nagle M W, Wilk J B, Massood T, Laramie J M, DeStefano A L, Litvan I, Nicholson G, Corbett A, Isaacson S, Burn D J, Chinnery P F, Pramstaller P P, Sherman S, Al-hinti J, Drasby E, Nance M, Moller A T, Ostergaard K, Roxburgh R, Snow B, Slevin J T, Cambi F, Gusella J F, Myers R H
Abstract excerpt
BACKGROUND: Microtubule-associated protein tau (MAPT) has been associated with several neurodegenerative disorders including forms of parkinsonism and Parkinson disease (PD). We evaluated the association of the MAPT region with PD in a large cohort of familial PD cases recruited by the GenePD Study. In addition, postmortem brain samples from patients with PD and neurologically normal controls were used to...
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