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Article

Variants in the SNCA gene associate with motor progression while variants in the MAPT gene associate with the severity of Parkinson's disease.

Parkinsonism & related disorders - 1 Mar 2016

Wang Gang, Huang Yue, Chen Wei, Chen Shuai, Wang Ying, Xiao Qin, Liu Jun, Fung Victor S C, Halliday Glenda, Chen Shengdi

Abstract excerpt

INTRODUCTION: It is well known that α-synuclein (SNCA) and microtubule associated protein (MAPT) genes predispose individuals to develop Parkinson's disease (PD). However, whether these genes contribute to differences in the variable progression observed in PD is obscure. This study aims to evaluate the association of common variants in SNCA (rs11931074, rs894278) and MAPT (rs242557_H1c haplotype, rs3744456)...

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Source

Identifiers

PMID: 26776090
DOI: 10.1016/j.parkreldis.2015.12.018

Genes

MAPT
SNCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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