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Article

Inhibition of host cell translation elongation by Legionella pneumophila blocks the host cell unfolded protein response

23 Nov 2015

Abstract excerpt

Cells of the innate immune system recognize bacterial pathogens by detecting common microbial patterns as well as pathogen-specific activities. One system that responds to these stimuli is the IRE1 branch of the unfolded protein response (UPR), a sensor of endoplasmic reticulum (ER) stress. Activation of IRE1, in the context of Toll-like receptor (TLR) signaling, induces strong proinflammatory cytokine induction....

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PMID: 26598709
DOI: 10.1073/pnas.1508716112

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