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Article

A minimally invasive assay for individual assessment of the ATM/CHEK2/p53 pathway activity

1 Apr 2011

Abstract excerpt

Ionizing radiation induces DNA Double-Strand Breaks (DSBs) which activate the ATM/CHEK2/p53 pathway leading to cell cycle arrest and apoptosis through transcription of genes including CDKN1A (p21) and BBC3 (PUMA). This pathway prevents genomic instability and tumorigenesis as demonstrated in heritable syndromes [e.g. Ataxia Telangiectasia (AT); Li-Fraumeni syndrome (LFS)]. Here, a simple assay based on gene...

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PMID: 21389785
DOI: 10.4161/cc.10.7.15231

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