Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ATM function and its relationship with ATM gene mutations in chronic lymphocytic leukemia with the recurrent deletion (11q22.3-23.2).

Blood cancer journal - 2 Sept 2016

Jiang Y, Chen H-C, Su X, Thompson P A, Liu X, Do K-A, Wierda W, Keating M J, Plunkett W

Abstract excerpt

Approximately 10-20% of chronic lymphocytic leukemia (CLL) patients exhibit del(11q22-23) before treatment, this cohort increases to over 40% upon progression following chemoimmunotherapy. The coding sequence of the DNA damage response gene, ataxia-telangiectasia-mutated (ATM), is contained in this deletion. The residual ATM allele is frequently mutated, suggesting a relationship between gene function and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ataxia Telangiectasia Mutated Proteins
Share to Cell Cycle Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomal Proteins, Non-Histone

Share to Chromosome Deletion

Share to Chromosomes, Human, Pair 11

Share to Germ-Line Mutation

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Structural Maintenance of Chromosome Protein 1

Source

Open in PubMed Open full text

Identifiers

PMID: 27588518
DOI: 10.1038/bcj.2016.69
PMCID: PMC5056966

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ATM function and its relationship with ATM gene mutations in chronic lymphocytic leukemia with the recurrent deletion (11q22.3-23.2).PMID 27588518Read ↗

The role of ATM in DNA damage responses and cancer.Semantic proximity Read ↗

ATM gene alterations in chronic lymphocytic leukemia patients induce a distinct gene expression profile and predict disease progression.Semantic proximity Read ↗

DNA Damage Responses: Mechanisms and Roles in Human DiseaseSemantic proximity Read ↗

Incidence and clinical implications of ATM aberrations in chronic lymphocytic leukemia.Semantic proximity Read ↗

The role of ATM mutations and 11q deletions in disease progression in chronic lymphocytic leukemia.Semantic proximity Read ↗

Biallelic ATM inactivation significantly reduces survival in patients treated on the United Kingdom Leukemia Research Fund Chronic Lymphocytic Leukemia 4 trial.Semantic proximity Read ↗

Rapid Flow Cytometry–Based Structural Maintenance of Chromosomes 1 (SMC1) Phosphorylation Assay for Identification of Ataxia-Telangiectasia Homozygotes and HeterozygotesSemantic proximity Read ↗

Targeting ATM-deficient CLL through interference with DNA repair pathwaysSemantic proximity Read ↗

The ATM-dependent DNA damage signaling pathway.Semantic proximity Read ↗

Pathogenic ATM Mutations in Cancer and a Genetic Basis for Radiotherapeutic Efficacy.Semantic proximity Read ↗

Ataxia-telangiectasia mutated kinase (ATM) as a central regulator of radiation-induced DNA damage response.Semantic proximity Read ↗

Mutation status of the residual ATM allele is an important determinant of the cellular response to chemotherapy and survival in patients with chronic lymphocytic leukemia containing an 11q deletion.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.