Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Discordant gene responses to radiation in humans and mice and the role of hematopoietically humanized mice in the search for radiation biomarkers

19 Dec 2019

Abstract excerpt

The mouse (Mus musculus) is an extensively used model of human disease and responses to stresses such as ionizing radiation. As part of our work developing gene expression biomarkers of radiation exposure, dose, and injury, we have found many genes are either up-regulated (e.g. CDKN1A, MDM2, BBC3, and CCNG1) or down-regulated (e.g. TCF4 and MYC) in both species after irradiation at ~4 and 8 Gy. However, we have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Effects of Radiation Exposure
Share to Heat shock proteins research
Share to Molecular Biology Techniques and Applications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31857640
DOI: 10.1038/s41598-019-55982-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Discordant gene responses to radiation in humans and mice and the role of hematopoietically humanized mice in the search for radiation biomarkersPMID 31857640Read ↗

Discordant gene responses to radiation in humans and mice: hematopoietically humanized mice may save the day for radiation biomarker identificationSemantic proximity Read ↗

Candidate protein markers for radiation biodosimetry in the hematopoietically humanized mouse modelSemantic proximity Read ↗

Gene Expression Signatures That Predict Radiation Exposure in Mice and HumansSemantic proximity Read ↗

Cross-platform validation of a mouse blood gene signature for quantitative reconstruction of radiation doseSemantic proximity Read ↗

Identification of Radiation-Dose-Dependent Expressive Genes in Individuals Exposed to External Ionizing RadiationSemantic proximity Read ↗

Developing Human Radiation Biodosimetry Models: Testing Cross-Species Conversion Approaches Using an Ex Vivo Model SystemSemantic proximity Read ↗

Gene Expression Signatures of Radiation Response Are Specific, Durable and Accurate in Mice and HumansSemantic proximity Read ↗

Global Gene Expression Response in Mouse Models of DNA Repair Deficiency after Gamma Irradiation.Semantic proximity Read ↗

Mouse models for radiation-induced cancersSemantic proximity Read ↗

Identification of Differential Gene Expression Patterns after Acute Exposure to High and Low Doses of Low-LET Ionizing Radiation in a Reconstituted Human Skin TissueSemantic proximity Read ↗

Mouse Genomic Associations with <i>Ex Vivo</i> Sensitivity to Simulated Space RadiationSemantic proximity Read ↗

Evolutionarily conserved serum microRNAs predict radiation-induced fatality in nonhuman primatesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.