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Article

Mice with the CHEK2*1100delC SNP are predisposed to cancer with a strong gender bias.

Proceedings of the National Academy of Sciences of the United States of America - 6 Oct 2009

Bahassi El Mustapha, Robbins Susan B, Yin Moying, Boivin Gregory P, Kuiper Raoul, van Steeg Harry, Stambrook Peter J

Abstract excerpt

The CHEK2 kinase (Chk2 in mouse) is a member of a DNA damage response pathway that regulates cell cycle arrest at cell cycle checkpoints and facilitates the repair of dsDNA breaks by a recombination-mediated mechanism. There are numerous variants of the CHEK2 gene, at least one of which, CHEK2*1100delC (SNP), associates with breast cancer. A mouse model in which the wild-type Chk2 has been replaced by a...

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Identifiers

PMID: 19805189
DOI: 10.1073/pnas.0909237106
PMCID: PMC2761365

Genes

CHEK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mice with the CHEK2*1100delC SNP are predisposed to cancer with a strong gender bias.PMID 19805189Read ↗

The breast cancer susceptibility allele CHEK2*1100delC promotes genomic instability in a knock-in mouse model.Semantic proximity Read ↗

Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations.Semantic proximity Read ↗

The CHEK2 gene and inherited breast cancer susceptibility.Semantic proximity Read ↗

Chk2*1100delC Acts in synergy with the Ron receptor tyrosine kinase to accelerate mammary tumorigenesis in mice.Semantic proximity Read ↗

The CHEK2*1100delC allelic variant and risk of breast cancer: screening results from the Breast Cancer Family Registry.Semantic proximity Read ↗

CHEK2 Germline Variants in Cancer Predisposition: Stalemate Rather than Checkmate.Semantic proximity Read ↗

Increased Risk for Other Cancers in Addition to Breast Cancer for CHEK2*1100delC Heterozygotes Estimated From the Copenhagen General Population Study.Semantic proximity Read ↗

Association Between CHEK2*1100delC and Breast Cancer: A Systematic Review and Meta-Analysis.Semantic proximity Read ↗

Analysis of familial male breast cancer for germline mutations in CHEK2.Semantic proximity Read ↗

Chek2 DNA damage response pathway and inherited breast cancer risk.Semantic proximity Read ↗

Current perspectives on CHEK2 mutations in breast cancerSemantic proximity Read ↗

Increased risk of breast cancer associated with CHEK2*1100delC.Semantic proximity Read ↗

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