Article

Discordant gene responses to radiation in humans and mice: hematopoietically humanized mice may save the day for radiation biomarker identification

2019-02-24

Abstract excerpt

The mouse ( Mus musculus ) is an extensively used model of human disease and responses to stresses such as ionizing radiation. As part of our work developing gene expression biomarkers of radiation exposure, dose, and injury, we have found many genes are either up-regulated (e.g. CDKN1A, MDM2, BBC3 , and CCNG1 ) or down-regulated (e.g. TCF4 and MYC ) in both species after irradiation. However, we have also fo...

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Literature Corpus work: 2fe8f068-e6ff-5475-8ebf-d1016dd06b4e
DOI: 10.1101/558882

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