Endothelial TGF-β signaling instructs smooth muscle cell development in the cardiac outflow tract

Abstract excerpt

The development of the cardiac outflow tract (OFT), which connects the heart to the great arteries, relies on a complex crosstalk between endothelial (ECs) and smooth muscle (SMCs) cells. Defects in OFT development can lead to severe malformations, including aortic aneurysms, which are frequently associated with impaired TGF-β signaling. To better understand the role of TGF-β signaling in OFT formation, we...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Aortic Disease and Treatment Approaches
• Share to Congenital heart defects research
• Share to Congenital Heart Disease Studies