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Article

Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis.

Proceedings of the National Academy of Sciences of the United States of America - 14 Mar 2000

Oh S P, Seki T, Goss K A, Imamura T, Yi Y, Donahoe P K, Li L, Miyazono K, ten Dijke P, Kim S, Li E

Abstract excerpt

The activin receptor-like kinase 1 (ALK1) is a type I receptor for transforming growth factor-beta (TGF-beta) family proteins. Expression of ALK1 in blood vessels and mutations of the ALK1 gene in human type II hereditary hemorrhagic telangiectasia patients suggest that ALK1 may have an important role during vascular development. To define the function of ALK1 during development, we inactivated the ALK1 gene in...

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Identifiers

PMID: 10716993
DOI: 10.1073/pnas.97.6.2626
PMCID: PMC15979

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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