Article
Interaction Between ALK1 Signaling and Connexin40 in the Development of Arteriovenous Malformations.
Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2016
Gkatzis Konstantinos, Thalgott Jérémy, Dos-Santos-Luis Damien, Martin Sabrina, Lamandé Noël, Carette Marie France, Disch Frans, Snijder Repke J, Westermann Cornelius J, Mager Johannes J, Oh S Paul, Miquerol Lucile, Arthur Helen M, Mummery Christine L, Lebrin Franck
Abstract excerpt
OBJECTIVE: To determine the role of Gja5 that encodes for the gap junction protein connexin40 in the generation of arteriovenous malformations in the hereditary hemorrhagic telangiectasia type 2 (HHT2) mouse model. APPROACH AND RESULTS: We identified GJA5 as a target gene of the bone morphogenetic protein-9/activin receptor-like kinase 1 signaling pathway in human aortic endothelial cells and importantly found...
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