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Article

Impaired IGF1R signaling in cells expressing longevity-associated human IGF1R alleles.

Aging cell - 1 Jun 2011

Tazearslan Cagdas, Huang Jing, Barzilai Nir, Suh Yousin

Abstract excerpt

Dampening of insulin/insulin-like growth factor-1 (IGF1) signaling results in the extension of lifespan in invertebrate as well as murine models. The impact of this evolutionarily conserved pathway on the modulation of human lifespan remains unclear. We previously identified two IGF1R mutations (Ala-37-Thr and Arg-407-His) that are enriched in Ashkenazi Jewish centenarians as compared to younger controls and are...

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Source

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Identifiers

PMID: 21388493
DOI: 10.1111/j.1474-9726.2011.00697.x
PMCID: PMC3094477

Genes

IGF1
EGR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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