Article
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice.
Nature - 9 Jan 2003
Holzenberger Martin, Dupont Joëlle, Ducos Bertrand, Leneuve Patricia, Géloën Alain, Even Patrick C, Cervera Pascale, Le Bouc Yves
Abstract excerpt
Studies in invertebrates have led to the identification of a number of genes that regulate lifespan, some of which encode components of the insulin or insulin-like signalling pathways. Examples include the related tyrosine kinase receptors InR (Drosophila melanogaster) and DAF-2 (Caenorhabditis elegans) that are homologues of the mammalian insulin-like growth factor type 1 receptor (IGF-1R). To investigate...
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