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Article

Influence of leukotriene pathway polymorphisms on clinical responses to montelukast in Japanese patients with asthma.

Journal of clinical pharmacy and therapeutics - 1 Feb 2012

Kotani H, Kishi R, Mouri A, Sashio T, Shindo J, Shiraki A, Hiramatsu T, Iwata S, Taniguchi H, Nishiyama O, Iwata M, Suzuki R, Gonda H, Niwa T, Kondo M, Hasegawa Y, Kume H, Noda Y

Abstract excerpt

WHAT IS KNOWN AND OBJECTIVE: Montelukast, a cysteinyl leukotriene receptor 1 antagonist, is safe and efficacious in patients with asthma. The mechanisms underlying the significant interpatient variability in response to montelukast are not clear but are believed to be, in part, because of genetic variability. METHODS: To examine the associations between polymorphisms in candidate genes in the leukotriene pathway...

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PMID: 21385196
DOI: 10.1111/j.1365-2710.2011.01248.x

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FEV
ALOX5

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