Article
GENETIC INTERACTIONS BETWEEN ADRB2 AND PTGER4 ON RESPONSES TO SALMETEROL OR MONTELUKAST IN JAPANESE PATIENTS WITH MILD PERSISTENT ASTHMA.
Arerugi = [Allergy] - 1 Jan 2016
Yamada Hideyasu, Masuko Hironori, Inui Toshihide, Kanazawa Jun, Yatagai Yohei, Sakamoto Tohru, Iijima Hiroaki, Konno Satoshi, Shimizu Kaoruko, Makita Hironi, Nishimura Masaharu, Kokubu Fumio, Saito Takefumi, Endo Takeo, Ninomiya Hiroki, Kaneko Norihiro, Hizawa Nobuyuki
Abstract excerpt
BACKGROUND: Long-acting β2-agonists (LABA) and leukotriene receptor antagonists (LTRA) are two principal agents that can be added to inhaled corticosteroids (ICS) for patients with asthma that is not adequately controlled by ICS alone. In our previous study, the Gly16Arg genotype of the β2-adrenergic receptor (ADRB2) gene did not influence the differential bronchodilator effect of salmeterol versus montelukast as...
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