Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphisms of the PTGDR and LTC4S influence responsiveness to leukotriene receptor antagonists in Korean children with asthma.

Journal of human genetics - 1 Apr 2011

Kang Mi-Jin, Kwon Ji-Won, Kim Byoung-Ju, Yu Jinho, Choi Won-Ah, Shin Yee-Jin, Hong Soo-Jong

Abstract excerpt

Activation of the prostaglandin D2 receptor (PTGDR) may contribute to pulmonary vasodilation, bronchoconstriction, recruitment of eosinophils, basophils and T-lymphocytes, and enhanced synthesis of leukotriene C4. We investigated whether polymorphisms of the leukotriene C4 synthase (LTC4S) -444A/C and PTGDR -441T/C were associated with clinical phenotypes and responsiveness to leukotriene receptor antagonist...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetates
Share to Cyclopropanes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Exercise Test

Share to Fluorescence

Share to Immunoglobulin E

Share to Quinolines

Share to Receptors, Prostaglandin

Share to Sulfides

Source

Identifiers

PMID: 21307858
DOI: 10.1038/jhg.2011.3

Genes

PTGDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms of the PTGDR and LTC4S influence responsiveness to leukotriene receptor antagonists in Korean children with asthma.PMID 21307858Read ↗

TBXA2R gene polymorphism and responsiveness to leukotriene receptor antagonist in children with asthma.Semantic proximity Read ↗

Leukotriene pathway genetics and pharmacogenetics in allergySemantic proximity Read ↗

PTGDR polymorphisms and susceptibility to asthma: a meta-analysis.Semantic proximity Read ↗

Association of IL-13 polymorphisms with leukotriene receptor antagonist drug responsiveness in Korean children with exercise-induced bronchoconstriction.Semantic proximity Read ↗

[The relevance of leukotriene C(4) synthase gene A (-444) C polymorphism to clinical responsiveness to montelukast in patients with asthma].Semantic proximity Read ↗

The -444A/C polymorphism in the LTC4S gene and the risk of asthma: a meta-analysis.Semantic proximity Read ↗

PTGDR is not a major candidate gene for asthma and atopy in Chinese children.Semantic proximity Read ↗

Influence of leukotriene pathway polymorphisms on clinical responses to montelukast in Japanese patients with asthma.Semantic proximity Read ↗

GENETIC INTERACTIONS BETWEEN ADRB2 AND PTGER4 ON RESPONSES TO SALMETEROL OR MONTELUKAST IN JAPANESE PATIENTS WITH MILD PERSISTENT ASTHMA.Semantic proximity Read ↗

Polymorphisms in toll-like receptor 4 gene are associated with asthma severity but not susceptibility in a Chinese Han population.Semantic proximity Read ↗

No association of PTGDR -441C/T polymorphism with asthma in a North Indian population.Semantic proximity Read ↗

Cysteinyl Leukotrienes Pathway Genes, Atopic Asthma and Drug Response: From Population Isolates to Large Genome-Wide Association StudiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.