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Article

CysLTR1 Promoter Polymorphism and Requirement for Leukotriene Receptor Antagonist in Aspirin-Intolerant Asthma Patients

1 Sept 2007

Abstract excerpt

OBJECTIVES: Leukotriene receptor antagonists (LTRA), such as montelukast, have been used as a first-line treatment for patients with aspirin-intolerant asthma (AIA). This study evaluated associations between the clinical requirement for LTRA and genetic polymorphisms of the ALOX5, LTC4S, COX-2, CysLTR1 and TBXA2R genes in the arachidonic acid cascade in the long-term management of 89 AIA patients from a Korean...

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PMID: 17924829
DOI: 10.2217/14622416.8.9.1143

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