Article
How mutations in tRNA distant from the anticodon affect the fidelity of decoding.
Nature structural & molecular biology - 1 Apr 2011
Schmeing T Martin, Voorhees Rebecca M, Kelley Ann C, Ramakrishnan V
Abstract excerpt
The ribosome converts genetic information into protein by selecting aminoacyl tRNAs whose anticodons base-pair to an mRNA codon. Mutations in the tRNA body can perturb this process and affect fidelity. The Hirsh suppressor is a well-studied tRNA(Trp) harboring a G24A mutation that allows readthrough of UGA stop codons. Here we present crystal structures of the 70S ribosome complexed with EF-Tu and aminoacyl tRNA...
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