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Article

Ribosomal ambiguity (ram) mutations promote the open (off) to closed (on) transition and thereby increase miscoding.

Nucleic acids research - 20 Feb 2019

Hoffer Eric D, Maehigashi Tatsuya, Fredrick Kurt, Dunham Christine M

Abstract excerpt

Decoding is thought to be governed by a conformational transition in the ribosome-open (off) to closed (on)-that occurs upon codon-anticodon pairing in the A site. Ribosomal ambiguity (ram) mutations increase miscoding and map to disparate regions, consistent with a role for ribosome dynamics in decoding, yet precisely how these mutations act has been unclear. Here, we solved crystal structures of 70S ribosomes...

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Share to Anticodon
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Share to Crystallography, X-Ray

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to RNA, Ribosomal, 16S

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Identifiers

PMID: 30476222
DOI: 10.1093/nar/gky1178
PMCID: PMC6379664

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ASL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Ribosomal ambiguity (ram) mutations promote the open (off) to closed (on) transition and thereby increase miscoding.PMID 30476222Read ↗

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