Article
Anticodon loop mutations perturb reading frame maintenance by the E site tRNA.
RNA (New York, N.Y.) - 1 Sept 2008
Sanders Christina L, Lohr Kristin J, Gambill Holly L, Curran Ryan B, Curran James F
Abstract excerpt
The ribosomal E site helps hold the reading frame. Certain tRNA mutations affect translation, and anticodon loop mutations can be especially detrimental. We studied the effects of mutations saturating the anticodon loop of the amber suppressor tRNA, Su7, on the ability to help hold the reading frame when in the E site. We also tested three mutations in the anticodon stem, as well as a mutation in the D stem (the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.