Article
Functional elucidation of a key contact between tRNA and the large ribosomal subunit rRNA during decoding.
RNA (New York, N.Y.) - 1 Oct 2010
Ortiz-Meoz Rodrigo F, Green Rachel
Abstract excerpt
The selection of cognate tRNAs during translation is specified by a kinetic discrimination mechanism driven by distinct structural states of the ribosome. While the biochemical steps that drive the tRNA selection process have been carefully documented, it remains unclear how recognition of matched codon:anticodon helices in the small subunit facilitate global rearrangements in the ribosome complex that...
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