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Article

Characterization of ERM transactivation domain binding to the ACID/PTOV domain of the Mediator subunit MED25.

Nucleic acids research - 18 Aug 2015

Landrieu Isabelle, Verger Alexis, Baert Jean-Luc, Rucktooa Prakash, Cantrelle François-Xavier, Dewitte Frédérique, Ferreira Elisabeth, Lens Zoé, Villeret Vincent, Monté Didier

Abstract excerpt

The N-terminal acidic transactivation domain (TAD) of ERM/ETV5 (ERM38-68), a PEA3 group member of Ets-related transcription factors, directly interacts with the ACID/PTOV domain of the Mediator complex subunit MED25. Molecular details of this interaction were investigated using nuclear magnetic resonance (NMR) spectroscopy. The TAD is disordered in solution but has a propensity to adopt local transient secondary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26130716
DOI: 10.1093/nar/gkv650
PMCID: PMC4538835

Genes

MED25
ETV5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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