Article
CD8+ T-cell response promotes evolution of hepatitis C virus nonstructural proteins.
Gastroenterology - 1 Jun 2011
Ruhl Marianne, Knuschke Torben, Schewior Kevin, Glavinic Lejla, Neumann-Haefelin Christoph, Chang Dae-In, Klein Marina, Heinemann Falko M, Tenckhoff Hannelore, Wiese Manfred, Horn Peter A, Viazov Sergei, Spengler Ulrich, Roggendorf Michael, Scherbaum Norbert, Nattermann Jacob, Hoffmann Daniel, Timm Jörg
Abstract excerpt
BACKGROUND & AIMS: Hepatitis C virus (HCV) acquires mutations that allow it to escape the CD8+ T-cell response, although the extent to which this process contributes to viral evolution at the population level is not clear. We studied viral adaptation using data from a large outbreak of HCV genotype 1b infection that occurred among women immunized with contaminated immunoglobulin from 1977 to 1978. METHODS: The...
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