Article
Effect of immune pressure on hepatitis C virus evolution: insights from a single-source outbreak.
Hepatology (Baltimore, Md.) - 1 Feb 2011
Merani Shahzma, Petrovic Danijela, James Ian, Chopra Abha, Cooper Don, Freitas Elizabeth, Rauch Andri, di Iulio Julia, John Mina, Lucas Michaela, Fitzmaurice Karen, McKiernan Susan, Norris Suzanne, Kelleher Dermot, Klenerman Paul, Gaudieri Silvana
Abstract excerpt
UNLABELLED: The host's immune response to hepatitis C virus (HCV) can result in the selection of characteristic mutations (adaptations) that enable the virus to escape this response. The ability of the virus to mutate at these sites is dependent on the incoming virus, the fitness cost incurred by...
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