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Article

Adaptation of the hepatitis B virus core protein to CD8+ T‐cell selection pressure

26 Feb 2015

Abstract excerpt

UNLABELLED: Activation of hepatitis B virus (HBV)-specific CD8 T cells by therapeutic vaccination may promote sustained control of viral replication by clearance of covalently closed circular DNA from infected hepatocytes. However, little is known about the exact targets of the CD8 T-cell response and whether HBV reproducibly evades CD8 T-cell immune pressure by mutation. The aim of this study was to address if...

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PMID: 25720337
DOI: 10.1002/hep.27771

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