Article
Constrained pattern of viral evolution in acute and early HCV infection limits viral plasticity.
PloS one - 8 Feb 2011
Pfafferott Katja, Gaudieri Silvana, Ulsenheimer Axel, James Ian, Heeg Malte, Nolan David, John Mina, Rauch Andri, Mallal Simon, Lucas Andrew, Klenerman Paul, Diepolder Helmut M, Lucas Michaela
Abstract excerpt
Cellular immune responses during acute Hepatitis C virus (HCV) and HIV infection are a known correlate of infection outcome. Viral adaptation to these responses via mutation(s) within CD8+ T-cell epitopes allows these viruses to subvert host immune control. This study examined HCV evolution in 21 HCV genotype 1-infected subjects to characterise the level of viral adaptation during acute and early HCV infection....
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