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Article

Hepatitis C virus drug resistance and immune-driven adaptations: relevance to new antiviral therapy.

Hepatology (Baltimore, Md.) - 1 Apr 2009

Gaudieri Silvana, Rauch Andri, Pfafferott Katja, Barnes Eleanor, Cheng Wendy, McCaughan Geoff, Shackel Nick, Jeffrey Gary P, Mollison Lindsay, Baker Ross, Furrer Hansjakob, Günthard Huldrych F, Freitas Elizabeth, Humphreys Isla, Klenerman Paul, Mallal Simon, James Ian, Roberts Stuart, Nolan David, Lucas Michaela

Abstract excerpt

UNLABELLED: The efficacy of specifically targeted anti-viral therapy for hepatitis C virus (HCV) (STAT-C), including HCV protease and polymerase inhibitors, is limited by the presence of drug-specific viral resistance mutations within the targeted proteins. Genetic diversity within these viral proteins also evolves under selective pressures provided by host human leukocyte antigen (HLA)-restricted immune...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19263475
DOI: 10.1002/hep.22773

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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