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Article

Retrospective molecular and phenotypic analysis of poliovirus vaccine strains isolated in Greece.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases - 1 Oct 2011

Pliaka V, Filliponi M E, Kyriakopoulou Z, Ruether I G A, Tsakogiannis D, Gartzonika C, Levidiotou-Stefanou S, Markoulatos P

Abstract excerpt

The live oral poliovirus vaccine (OPV) strains are genetically unstable, causing, in rare cases, vaccine-associated paralytic poliomyelitis. Reversions of the known attenuating mutations in OPV strains and intertypic recombination have been identified as the underlying causes of the increased neurovirulence of poliovirus isolates. In this study, three OPV isolates (one non-recombinant and two recombinants) were...

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PMID: 21375661
DOI: 10.1111/j.1469-0691.2011.03470.x

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