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Article

Vaccine-derived poliovirus (VDPV): Impact on poliomyelitis eradication.

Vaccine - 5 May 2009

Minor Philip

Abstract excerpt

The live attenuated strains used in the oral poliovirus (OPV) have been the main tool in the WHO polio eradication programme. However, these strains replicate in the human gut and are excreted for several weeks after immunisation. During this period, the attenuating mutations in the vaccine strains can rapidly revert. This may, in rare cases, cause vaccine-associated paralytic poliomyelitis (VAPP) in vaccinees or...

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Identifiers

PMID: 19428874
DOI: 10.1016/j.vaccine.2009.02.071

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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