Article
Oral poliovaccine: will it help eradicate polio or cause the next epidemic?
The Israel Medical Association journal : IMAJ - 1 May 2006
Shulman Lester M, Manor Yosef, Sofer Danit, Swartz Tiberio, Mendelson Ella
Abstract excerpt
BACKGROUND: Poliovirus rapidly evolves by nucleic acid substitutions and genetic recombination with other polioviruses and non-polio enteroviruses. Evolving oral poliovaccine can rapidly revert to neurovirulence and undergo antigenic alterations. OBJECTIVES: To evaluate the threat of vaccine-derived poliovirus (1-15% divergence from the respective Sabin strain) for a poliomyelitis-free population in a country...
Topics
- Adolescent
- Antibodies, Viral
- Child
- Child, Preschool
- Enterovirus
- Genetic Variation
- Humans
- Infant
- Poliomyelitis
- Poliovirus
- Poliovirus Vaccine, Oral
- Recombination, Genetic
- Sewage