Article

Developing genetically stable live-attenuated vaccine candidates against type 1 and 3 poliovirus

2022-12-09

Abstract excerpt

<title>Abstract</title> <p>Vaccination with Sabin oral poliovirus vaccine (OPV) results in robust intestinal and humoral immunity and has been key to controlling poliomyelitis. However, as with any RNA virus, OPV can evolve rapidly . During replication, OPV strains can lose their attenuating mutations—polymorphisms in domain V of the 5′ untranslated region are critical to the reacquisition of virulence —and the r...

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Identifiers and source

Literature Corpus work: bbe356f3-c34e-549e-b0b6-c81ea93b631d
DOI: 10.21203/rs.3.rs-2306887/v1

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